BMS-690514
BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR; has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.
Product Specifications
CAS Number
859853-30-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EGFR; VEGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/BMS-690514.html
Concentration
10mM
Purity
99.68
Solubility
DMSO : ≥ 25 mg/mL
Smiles
O[C@@H]1CN(CC[C@H]1N)CC2=C3C(NC4=CC=CC(OC)=C4)=NC=NN3C=C2
Molecular Formula
C19H24N6O2
Molecular Weight
368.43
Precautions
H302, H315, H319, H335
References & Citations
[1]Wong TW, et al. Antitumor and antiangiogenic activities of BMS-690514, an inhibitor of human EGF and VEGF receptor kinase families. Clin Cancer Res. 2011 Jun 15;17 (12) :4031-41.|[2]Marathe P, et al. Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2. J Pharm Sci. 2010 Aug;99 (8) :3579-93.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
EGFR/ErbB1/HER1; ErbB2/HER2; ErbB4/HER4; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4
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