Oxadiazon

Oxadiazon is an orally active herbicide. Oxadiazon reduces hepatic cytochrome P450 levels. Oxadiazon increases palmitoyl CoA oxidase, acetyl carnitine transferase, and hepatic ALAS activity. Oxadiazon induces hepatomegaly and experimental porphyria. Oxadiazon controls weeds. Oxadiazon may be used in neurodegenerative disease research[1][2][3][4][5].

Product Specifications

CAS Number

[19666-30-9]

UNSPSC

12352005

Hazard Statement

H350, H360, H410

Target

Cytochrome P450; Herbicide

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Oxadiazon.html

Purity

98.51

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C1OC(C(C)(C)C)=NN1C2=CC(OC(C)C)=C(Cl)C=C2Cl

Molecular Formula

C15H18Cl2N2O3

Molecular Weight

345.22

Precautions

H350, H360, H410

References & Citations

[1]Ying G G, et al. The degradation of oxadiazon and oxyfluorfen by photolysis. Journal of Environmental Science & Health Part B, 1999, 34 (4) : 549-567. |[2]Navalon A, et al. Determination of tebufenpyrad and oxadiazon by solid-phase microextraction and gas chromatography-mass spectrometry. Chromatographia, 2001, 54 (5) : 377-382.|[3]Degl'Innocenti D, et al. Oxadiazon affects the expression and activity of aldehyde dehydrogenase and acylphosphatase in human striatal precursor cells: A possible role in neurotoxicity. Toxicology. 2019 Jan 1;411:110-121.|[4]Krijt J, et al. Experimental hepatic porphyria induced by oxadiazon in male mice and rats. Pesticide Biochemistry and Physiology, 1992, 42 (2) : 180-187. |[5]Richert L, et al. Comparison of the induction of hepatic peroxisome proliferation by the herbicide oxadiazon in vivo in rats, mice, and dogs and in vitro in rat and human hepatocytes. Toxicol Appl Pharmacol. 1996 Nov;141 (1) :35-43.