Curvularin
Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM[1][2].
Product Specifications
CAS Number
10140-70-2
Product Name Alternative
(S) -Curvularin
UNSPSC
12352005
Hazard Statement
H302
Target
NO Synthase
Type
Natural Products
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Infection
Assay Protocol
https://www.medchemexpress.com/curvularin.html
Solubility
10 mM in DMSO
Smiles
O=C(O[C@@H](C)CCCCC1)CC2=CC(O)=CC(O)=C2C1=O
Molecular Formula
C16H20O5
Molecular Weight
292.33
Precautions
P264-P270-P330-P501
References & Citations
[1]Kumar CG, et al. Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India. Springerplus. 2013 Dec;2 (1) :122.|[2]Yao Y, et al. Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi. Mol Pharmacol. 2003 Feb;63 (2) :383-91.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
INOS
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC681602-100 1x 100 µL
CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (ERIC-1), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
