Curvularin
Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM[1][2].
Product Specifications
CAS Number
10140-70-2
Product Name Alternative
(S) -Curvularin
UNSPSC
12352005
Hazard Statement
H302
Target
NO Synthase
Type
Natural Products
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Infection
Assay Protocol
https://www.medchemexpress.com/curvularin.html
Solubility
10 mM in DMSO
Smiles
O=C(O[C@@H](C)CCCCC1)CC2=CC(O)=CC(O)=C2C1=O
Molecular Formula
C16H20O5
Molecular Weight
292.33
Precautions
P264-P270-P330-P501
References & Citations
[1]Kumar CG, et al. Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India. Springerplus. 2013 Dec;2 (1) :122.|[2]Yao Y, et al. Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi. Mol Pharmacol. 2003 Feb;63 (2) :383-91.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
INOS
Available Sizes
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