GCN2iB
GCN2iB is an ATP-competitive inhibitor of a serine/threonine-protein kinase general control nonderepressible 2 (GCN2), with an IC50 of 2.4 nM.
Product Specifications
CAS Number
[2183470-12-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Eukaryotic Initiation Factor (eIF)
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GCN2iB.html
Concentration
10mM
Purity
99.83
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(C1=CC(Cl)=CN=C1OC)(NC2=CC=C(F)C(C#CC3=CN=C(N)N=C3)=C2F)=O
Molecular Formula
C18H12ClF2N5O3S
Molecular Weight
451.83
Precautions
H302, H315, H319, H335
References & Citations
[1]Nakamura A, et al. Inhibition of GCN2 sensitizes ASNS-low cancer cells by disrupting the amino acid response. Proc Natl Acad Sci U S A. 2018 Aug 14;115 (33) :E7776-E7785.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EIF2
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
LV681437 1.0 µg DNA
LCMT2 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)
Sign In for Pricing
View Details 
HP206999 200 Reactions
ARD1A (NAA10) Human qPCR Primer Pair (NM_003491)
Sign In for Pricing
View Details 
RC217047L4V 200 µL
TMC1 (NM_138691) Human Tagged ORF Clone Lentiviral Particle
Sign In for Pricing
View Details