Nefazodone (hydrochloride)

Nefazodone hydrochloride (BMY-13754) is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively) . Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity[1][2].

Product Specifications

CAS Number

[82752-99-6]

Product Name Alternative

BMY-13754; MJ-13754-1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335, H373

Target

5-HT Receptor; Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Nefazodone-hydrochloride.html

Purity

99.94

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic)

Smiles

O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)N=C(CC)N1CCOC4=CC=CC=C4.[H]Cl

Molecular Formula

C25H33Cl2N5O2

Molecular Weight

506.47

Precautions

H302, H315, H319, H335, H373

References & Citations

[1]Pullar IA, et al. LY367265, an inhibitor of the 5-hydroxytryptamine transporter and 5-hydroxytryptamine (2A) receptor antagonist: a comparison with the antidepressant, nefazodone. Eur J Pharmacol. 2000;407 (1-2) :39-46.|[2]Ellingrod VL, et al. Nefazodone: a new antidepressant. Am J Health Syst Pharm. 1995;52 (24) :2799-2812.