FMF-06-098-1
FMF-06-098-1 is a multi-target kinase PROTAC degrader. FMF-06-098-1 can be used to target degradation kinases which degrades AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1 (Pink: target protein ligand (HY-169396) ; Blue: VHL ligand (HY-112078) ; Black: Linker (HY-124380) ) [1].
Product Specifications
CAS Number
[2769753-07-1]
UNSPSC
12352005
Target
AAK1; CDK; Ephrin Receptor; FGFR; IRAK; Itk; MAP4K; MELK; p38 MAPK; PROTACs; ULK; Wee1
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; PI3K/Akt/mTOR; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fmf-06-098-1.html
Purity
98.77
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
Molecular Formula
C53H69ClN10O8S2
Molecular Weight
1073.76
References & Citations
[1]Nathanael GS, et, al. Bifunctional compounds for targeted protein degradation of kinases. WO2022093742.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
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