FMF-06-098-1

FMF-06-098-1 is a multi-target kinase PROTAC degrader. FMF-06-098-1 can be used to target degradation kinases which degrades AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1 (Pink: target protein ligand (HY-169396) ; Blue: VHL ligand (HY-112078) ; Black: Linker (HY-124380) ) [1].

Product Specifications

CAS Number

[2769753-07-1]

UNSPSC

12352005

Target

AAK1; CDK; Ephrin Receptor; FGFR; IRAK; Itk; MAP4K; MELK; p38 MAPK; PROTACs; ULK; Wee1

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; PI3K/Akt/mTOR; PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fmf-06-098-1.html

Purity

98.77

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)S(C(C=CC=C1)=C1NC2=NC(NC(C=C3)=CC=C3N(CC4)CCN4CCOCCOCCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O)=NC=C2Cl)(=O)=O