PEG2000-DMPE

PEG2000-DMPE can be used to synthsis a LNP. PEG2000-DMPE enhances the entrapment efficiency depending on the increasing portion in the liposome. The optimal formulation for animal study is that DMPC/PEG2000-DMPE/CH=50/5/45 at the weight ratio of drug/lipid=1/20[1].

Product Specifications

UNSPSC

12352211

Target

Liposome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/peg2000-dmpe.html

Purity

99.70

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCCCCCCCCCCC(O[C@](COP(OCCNC(OCCOC)=O)(O)=O)([H])COC(CCCCCCCCCCCCC)=O)=O

Molecular Formula

C125H248NO55P

Molecular Weight

2676.25

References & Citations

[1]Han I, et al. Enhanced antitumor activity [correction for activitiy] of trans (+/-) -1,2-diaminocyclo- hexaneglutamatoplatinum (II) formulated with stealth liposome. Bioorg Med Chem. 2003 Dec 1;11 (24) :5443-7.