NSC-87877
Product Specifications
UNSPSC Description
NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2].
Target Antigen
Apoptosis; Phosphatase; SHP2
Type
Reference compound
Related Pathways
Apoptosis;Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/nsc-87877.html
Purity
99.0
Solubility
DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 23.81 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=S(C1=C2C=CC=NC2=C(O)C(/N=N/C3=CC=C4C=C(S(=O)(O)=O)C=CC4=C3)=C1)(O)=O
Molecular Weight
459.45
References & Citations
[1]Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70.|[2]Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5.|[3]Y Shi, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 6;6(8):e1841.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-18756/NSC-87877-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-18756/NSC-87877-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
56990-57-9
Available Sizes
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