NSC-87877

NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26) [2].

Product Specifications

CAS Number

[56990-57-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Phosphatase; SHP1; SHP2

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/nsc-87877.html

Purity

99.0

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=S(C1=C2C=CC=NC2=C(O)C(/N=N/C3=CC=C4C=C(S(=O)(O)=O)C=CC4=C3)=C1)(O)=O

Molecular Formula

C19H13N3O7S2

Molecular Weight

459.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70 (2) :562-70.|[2]Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26) . Biochem Biophys Res Commun. 2009 Apr 17;381 (4) :491-5.|[3]Y Shi, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 6;6 (8) :e1841.