L-902688
L-902688 is a potent, selective and orally active EP4 receptor agonist with a Ki of 0.38 nM and an EC50 of 0.6 nM. L-902688 shows >4,000-fold selective for EP4 over other EP and prostanoid receptors[1][2].
Product Specifications
CAS Number
634193-54-7
Product Name Alternative
GCA-1
UNSPSC
12352005
Hazard Statement
H225, H301+H311+H331, H370
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/l-902688.html
Concentration
11.92 mM * 200 μL in Methanol
Purity
99.0
Solubility
10 mM in DMSO
Smiles
O[C@@]([H])(C(F)(C1=CC=CC=C1)F)/C=C/[C@@H](CCC2=O)N2CCCCCCC3=NN=NN3
Molecular Formula
C21H27F2N5O2
Molecular Weight
419.47
Precautions
H225, H301+H311+H331, H370
References & Citations
[1]Lai YJ, et al. EP4 Agonist L-902,688 Suppresses EndMT and Attenuates Right Ventricular Cardiac Fibrosis in Experimental Pulmonary Arterial Hypertension. Int J Mol Sci. 2018 Mar 3;19 (3) . pii: E727.|[2][2]Young, R.N., Billot, X., Han, Y., et al. Discovery and synthesis of a potent, selective and orally bioavailable EP4 receptor agonist. Heterocycles. 2004, 64, 437-445.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EP
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