L-902688

L-902688 is a potent, selective and orally active EP4 receptor agonist with a Ki of 0.38 nM and an EC50 of 0.6 nM. L-902688 shows >4,000-fold selective for EP4 over other EP and prostanoid receptors[1][2].

Product Specifications

CAS Number

[634193-54-7]

Product Name Alternative

GCA-1

UNSPSC

12352005

Hazard Statement

H225, H301+H311+H331, H370

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/l-902688.html

Concentration

11.92 mM * 200 μL in Methanol

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O[C@@]([H])(C(F)(C1=CC=CC=C1)F)/C=C/[C@@H](CCC2=O)N2CCCCCCC3=NN=NN3

Molecular Formula

C21H27F2N5O2

Molecular Weight

419.47

Precautions

H225, H301+H311+H331, H370

References & Citations

[1]Lai YJ, et al. EP4 Agonist L-902,688 Suppresses EndMT and Attenuates Right Ventricular Cardiac Fibrosis in Experimental Pulmonary Arterial Hypertension. Int J Mol Sci. 2018 Mar 3;19 (3) . pii: E727.|[2][2]Young, R.N., Billot, X., Han, Y., et al. Discovery and synthesis of a potent, selective and orally bioavailable EP4 receptor agonist. Heterocycles. 2004, 64, 437-445.