What is the catalog number for TT01001?

The catalog number for TT01001 is HY-114520.

What sizes are available for TT01001?

TT01001 is available in the following size(s): 5 mg, 10 mg, 25 mg, 50 mg.

How many pack sizes does TT01001 come in?

TT01001 is available in 4 different pack sizes.

TT01001 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures TT01001?

TT01001 is manufactured by QuantiMol.

What is the estimated delivery time for TT01001?

Estimated delivery time for TT01001 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for TT01001?

The safety data sheet for TT01001 is available here: http://file.medchemexpress.com/batch_PDF/HY-114520/TT01001-SDS-MedChemExpress.pdf.

TT01001

TT01001 is a selective and orally active mitoNEET agonist and a monoamine oxidase B (MAO-B) inhibitor (IC50 = 8.84 μM) . TT01001 does not activate PPARγ but interacts with MitoNEET. TT01001 attenuates oxidative stress and neuronal apoptosis by preventing mitoNEET-mediated mitochondrial dysfunction. TT01001 improves type II diabetes and ameliorates mitochondrial function of mice. TT01001 can used for the studies of type II diabetes and neurological disorders [1][2][3].

Product Specifications

CAS Number

1022367-69-6

Product Name Alternative

NSC144303

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Mitochondrial Metabolism; Monoamine Oxidase; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tt01001.html

Purity

99.38

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(OCC)N1CCC(CC1)NC(NC2=CC(Cl)=CC(Cl)=C2)=S

Molecular Formula

C15H19Cl2N3O2S

Molecular Weight

376.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Takehiro Takahashi, et al. A novel MitoNEET ligand, TT01001, improves diabetes and ameliorates mitochondrial function in db/db mice. J Pharmacol Exp Ther. 2015, 352, 2.|[2]Shi G, et al. TT01001 attenuates oxidative stress and neuronal apoptosis by preventing mitoNEET-mediated mitochondrial dysfunction after subarachnoid hemorrhage in rats. Neuroreport. 2020;31 (11) :845-850. |[3]Barbosa Belchior M, et al. Synthesis and evaluation of enzyme inhibition by novel TT01001 derivatives as monoamine oxidase B inhibitors. Bioorg Med Chem Lett. 2025 Mar 1;117:130045.