RECQL5-IN-1
Product Specifications
UNSPSC Description
RECQL5-IN-1 (Compound 4a) acts as an orally effective RECQL5 inhibitor (targeting both enzymatic and nonenzymatic domain). RECQL5-IN-1 is a potent inhibitor of RECQL5 helicase activity (IC50=46.3 nM). RECQL5-IN-1 inhibits RECQL5-WT cells and RECQL5-KO2 cells with IC50s of 4.8 μM and 19.6 μM, respectively. RECQL5-IN-1 can be used for the research of breast cancer[1].
Target Antigen
DNA/RNA Synthesis; Others
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/recql5-in-1.html
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
FC(F)(F)C1=CC(C(F)(F)F)=CC(NC(N[C@@H](C2=CC=CC=C2)C3=NN=C(SCC4=CC=CC=C4)O3)=O)=C1
Molecular Weight
552.49
References & Citations
[1]Saikat Chakraborty, et al. Targeting RECQL5 Functions, by a Small Molecule, Selectively Kills Breast Cancer in Vitr o and in Vivo. J Med Chem. 2021 Feb 11;64(3):1524-1544.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145685/RECQL5-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145685/RECQL5-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2718170-45-5
Available Sizes
Curated Selection
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