AZD-7762 (hydrochloride)
AZD-7762 hydrochloride is a potent ATP-competitive checkpoint kinase (Chk) inhibitor in with an IC50 of 5 nM for Chk1.
Product Specifications
CAS Number
1246094-78-9
UNSPSC
12352005
Hazard Statement
H302, H318
Target
Checkpoint Kinase (Chk)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azd-7762-hydrochloride.html
Purity
99.58
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C(NC(N)=O)C=C(C2=CC=CC(F)=C2)S1)N[C@@H]3CNCCC3.Cl
Molecular Formula
C17H20ClFN4O2S
Molecular Weight
398.88
Precautions
H302, H318
References & Citations
[1]Zabludoff SD, et al. AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol Cancer Ther. 2008 Sep;7 (9) :2955-66. |[2]Quin J, et al. Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling. Oncotarget. 2016 Aug 2;7 (31) :49800-49818.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Chk1; Chk2
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC881820-500 1x 500 µL
Ep-CAM / CD326 (Epithelial Marker) (rVU-1D9), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC682167-500 1x 500 µL
Emerin (Papillary Thyroid Carcinoma and EDMD Marker) (EMD/2167), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC682946-100 1x 100 µL
TLE1 (Synovial Sarcoma Marker) (TLE1/2946R), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC551365-500 1x 500 µL
Adipophilin / Perilipin-2 (Marker of Obesity) (ADFP/1365), CF555 conjugate, 0.1mg/mL
Sign In for Pricing
View Details