PhosTAC3
PhosTAC3 is a phosphorylation targeting chimera (PhosTAC) molecule composed of a linker with three PEG groups. PhosTAC3 induces dephosphorylation of PDCD4 and FOXO3a[1].
Product Specifications
UNSPSC
12352005
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/phostac3.html
Concentration
10mM
Purity
99.97
Solubility
DMSO : 130 mg/mL (ultrasonic)
Smiles
O=C(NCCOCCOCCOCCCCCCCl)COC1=CC=CC([C@H](OC([C@@H]2CCCCN2C([C@H](C3=CC(OC)=C(OC)C(OC)=C3)CC)=O)=O)CCC4=CC(OC)=C(OC)C=C4)=C1
Molecular Formula
C50H71ClN2O13
Molecular Weight
943.56
References & Citations
[1]Chen PH, et al. Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs) . ACS Chem Biol. 2021 Dec 17;16 (12) :2808-2815.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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