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TCS 46b

TCS 46b (Compound 46b) is a potent, selective and orally active NMDA NR1A/2B receptor antagonist with an IC50 of 5.3 nM[1]. TCS 46b is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

302799-86-6

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tcs-46b.html

Purity

98.52

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1NC2=CC=C(C=C2N1)C#CCN3CCC(CC3)CC4=CC=CC=C4

Molecular Formula

C22H23N3O

Molecular Weight

345.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Wright JL, et al. Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1- (heteroarylalkynyl) -4-benzylpiperidines. J Med Chem. 2000 Sep 7;43 (18) :3408-19.|[2]Wright JL, et al. Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1- (heteroarylalkynyl) -4-benzylpiperidines. J Med Chem. 2000 Sep 7;43 (18) :3408-19.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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