PF-03463275 (hydrochloride)

PF-03463275 hydrochloride is a centrally penetrant, orally available, selective, and competitive GlyT1 (glycine transporter-1) reversible inhibitor, with a Ki of 11.6 nM. PF-03463275 hydrochloride has the potential for Schizophrenia research[1][2].

Product Specifications

CAS Number

[1173177-11-1]

UNSPSC

12352005

Target

GlyT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pf-03463275-hydrochloride.html

Smiles

O=C(C1=CN(C)C=N1)N(CC2=CC(Cl)=C(C=C2)F)C[C@@H]3[C@]4([H])[C@@]3([H])CN(C4)C.Cl.Cl

Molecular Formula

C19H24Cl3FN4O

Molecular Weight

449.78

References & Citations

[1]Lowe JA 3rd, et al. The discovery of a structurally novel class of inhibitors of the type 1 glycine transporter [published correction appears in Bioorg Med Chem Lett. 2009 Aug 15;19 (16) :4885. Bronk, Brian S [added]; Schaeffer, Eric [added]]. Bioorg Med Chem Lett. 2009;19 (11) :2974-2976.|[2]Liu CN, Pettersen B, Seitis G, Osgood S, Somps C. GlyT1 inhibitor reduces oscillatory potentials of the electroretinogram in rats. Cutan Ocul Toxicol. 2014;33 (3) :206-211.