PF-03463275 (hydrochloride)
Product Specifications
UNSPSC Description
PF-03463275 hydrochloride is a centrally penetrant, orally available, selective, and competitive GlyT1 (glycine transporter-1) reversible inhibitor, with a Ki of 11.6 nM. PF-03463275 hydrochloride has the potential for Schizophrenia research[1][2].
Target Antigen
GlyT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pf-03463275-hydrochloride.html
Smiles
O=C(C1=CN(C)C=N1)N(CC2=CC(Cl)=C(C=C2)F)C[C@@H]3[C@]4([H])[C@@]3([H])CN(C4)C.Cl.Cl
Molecular Weight
449.78
References & Citations
[1]Lowe JA 3rd, et al. The discovery of a structurally novel class of inhibitors of the type 1 glycine transporter [published correction appears in Bioorg Med Chem Lett. 2009 Aug 15;19(16):4885. Bronk, Brian S [added]; Schaeffer, Eric [added]]. Bioorg Med Chem Lett. 2009;19(11):2974-2976.|[2]Liu CN, Pettersen B, Seitis G, Osgood S, Somps C. GlyT1 inhibitor reduces oscillatory potentials of the electroretinogram in rats. Cutan Ocul Toxicol. 2014;33(3):206-211.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10716/PF-03463275-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10716/
Clinical Information
Phase 2
CAS Number
1173177-11-1
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Rabbit Polyclonal DDX10 Antibody [Janelia Fluor 549]](https://cdn.genprice.uk/genprice/genprice4.png)