Sesamolin

Sesamolin, isolated from Sesamum indicum, has antioxidative activity, Sesamolin inhibits lipid peroxidation and shows neuroprotection effect. Sesamolinl potently inhibits MAPK cascades by preventing phosphorylation of JNK, p38 MAPKs, and caspase-3 but not ERK-MAPK expression. Sesamolin is orally active[1][2][3][4].

Product Specifications

CAS Number

[526-07-8]

UNSPSC

12352005

Hazard Statement

H317

Target

Caspase; JNK; NF-κB; p38 MAPK; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sesamolin.html

Concentration

10mM

Purity

99.78

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[H][C@@]12[C@@](CO[C@@H]2C3=CC(OCO4)=C4C=C3)([H])[C@H](OC1)OC5=CC(OCO6)=C6C=C5

Molecular Formula

C20H18O7

Molecular Weight

370.35

Precautions

H317

References & Citations

[1]Dorothea Bedigian, et al. Sesamin, sesamolin and the origin of sesame. Biochemical Systematics and Ecology. Volume 13, Issue 2, 23 May 1985, Pages 133-139.|[2]Myung-Hwa Kang, et al. Sesamolin Inhibits Lipid Peroxidation in Rat Liver and Kidney. The Journal of Nutrition, Volume 128, Issue 6, June 1998, Pages 1018–1022.|[3]Rolis Chien‐Wei Hou, et al. Protective effects of sesamin and sesamolin on hypoxic neuronal and PC12 cells.|[4]Lim JS, et al. Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats. Br J Nutr. 2007 Jan;97 (1) :85-95.|[5]Yang X, et al., Sesamolin Protects Mice From Ovariectomized Bone Loss by Inhibiting Osteoclastogenesis and RANKL-Mediated NF-κB and MAPK Signaling Pathways. Front Pharmacol. 2021 Jun 14;12:664697.|[6]Yu J, et al., Sesamolin Alleviates Nonalcoholic Fatty Liver Disease through Modulating Gut Microbiota and Metabolites in High-Fat and High-Fructose Diet-Fed Mice. Int J Mol Sci. 2022 Nov 10;23 (22) :13853.