FAK-IN-10

FAK-IN-10 is an inhibitor of FAK with an IC50 of 76.3 μM. FAK-IN-10 exhibits antitumor activity against MCF-7 and A431 cell lines with IC50s of 4.23 and 0.78 μM, respectively[1].

Product Specifications

CAS Number

[491839-65-7]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

FAK

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fak-in-10.html

Purity

98.04

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(CSC1=NN=C(C2=CC=NC=C2)O1)C3=CC=C(C=C3)Br

Molecular Formula

C15H10BrN3O2S

Molecular Weight

376.23

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Zhang LR, et al. Synthesis, biological evaluation and molecular docking studies of novel 2- (1,3,4-oxadiazol-2-ylthio) -1-phenylethanone derivatives. Bioorg Med Chem. 2012 Jun 1;20 (11) :3615-21.