FAK-IN-10
FAK-IN-10 is an inhibitor of FAK with an IC50 of 76.3 μM. FAK-IN-10 exhibits antitumor activity against MCF-7 and A431 cell lines with IC50s of 4.23 and 0.78 μM, respectively[1].
Product Specifications
CAS Number
[491839-65-7]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
FAK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fak-in-10.html
Purity
98.04
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(CSC1=NN=C(C2=CC=NC=C2)O1)C3=CC=C(C=C3)Br
Molecular Formula
C15H10BrN3O2S
Molecular Weight
376.23
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Zhang LR, et al. Synthesis, biological evaluation and molecular docking studies of novel 2- (1,3,4-oxadiazol-2-ylthio) -1-phenylethanone derivatives. Bioorg Med Chem. 2012 Jun 1;20 (11) :3615-21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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