PD-1/PD-L1-IN-48

PD-1/PD-L1-IN-48 (compound HD10) is a potent inhibitor of PD-1/PD-L1 interaction, with an IC50 of 3.1 nM. PD-1/PD-L1-IN-48 plays an important role in cancer research[1].

Product Specifications

UNSPSC

12352005

Target

PD-1/PD-L1

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pd-1-pd-l1-in-48.html

Smiles

N#CC1=CN=CC(COC2=CC(OCC3=C(C(C4=CC5=C(OCCO5)C=C4)=CC=C3)C(F)F)=CC=C2CNCCO)=C1

Molecular Formula

C32H29F2N3O5

Molecular Weight

573.59

References & Citations

[1]Hua Zhang, et al. Design, Synthesis, and Antitumor Activity Evaluation of 2-Arylmethoxy-4- (2,2'-dihalogen-substituted biphenyl-3-ylmethoxy) Benzylamine Derivatives as Potent PD-1/PD-L1 Inhibitors. J Med Chem. 2023 Aug 10;66 (15) :10579-10603.