PD-1/PD-L1-IN-48
PD-1/PD-L1-IN-48 (compound HD10) is a potent inhibitor of PD-1/PD-L1 interaction, with an IC50 of 3.1 nM. PD-1/PD-L1-IN-48 plays an important role in cancer research[1].
Product Specifications
UNSPSC
12352005
Target
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pd-1-pd-l1-in-48.html
Smiles
N#CC1=CN=CC(COC2=CC(OCC3=C(C(C4=CC5=C(OCCO5)C=C4)=CC=C3)C(F)F)=CC=C2CNCCO)=C1
Molecular Formula
C32H29F2N3O5
Molecular Weight
573.59
References & Citations
[1]Hua Zhang, et al. Design, Synthesis, and Antitumor Activity Evaluation of 2-Arylmethoxy-4- (2,2'-dihalogen-substituted biphenyl-3-ylmethoxy) Benzylamine Derivatives as Potent PD-1/PD-L1 Inhibitors. J Med Chem. 2023 Aug 10;66 (15) :10579-10603.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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