Thalidomide-O-C6-NHBoc

Thalidomide-O-C6-NHBoc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Product Specifications

CAS Number

[2509093-23-4]

UNSPSC

12352005

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidomide-o-c6-nhboc.html

Purity

95.99

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(OC(C)(C)C)NCCCCCCOC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O

Molecular Formula

C24H31N3O7

Molecular Weight

473.52

References & Citations

[1]Daniel A. HARKI, et al. Compounds that degrade kinases and uses thereof. WO2020247537A1.|[2]Zhang NN, et al. A Thermostable mRNA Vaccine against COVID-19. Cell. 2020;182 (5) :1271-1283.e16.