4-Pyridoxic acid

4-Pyridoxic acid is an endogenous substrate of renal organic anion transporters (OAT1/3) and a catabolite of vitamin B6. 4-Pyridoxic acid is excreted through OAT1/3-mediated tubular active secretion, which can reflect OAT1/3 activity. Elevated plasma concentrations of 4-Pyridoxic acid are associated with decreased OAT1/3 activity in chronic kidney disease (CKD) and can be used as a biomarker to reflect the severity of knee osteoarthritis (KOA) and lumbar spondylosis (LS) [1][2][3][4].

Product Specifications

CAS Number

[82-82-6]

Product Name Alternative

PCR 5332

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/4-Pyridoxic_acid.html

Purity

99.82

Solubility

1 M NaOH : ≥ 100 mg/mL|DMSO : 5 mg/mL (ultrasonic; adjust pH to 8 with NaOH) |H2O : 4.85 mg/mL (ultrasonic; warming; adjust pH to 7 with NaOH; heat to 60°C)

Smiles

O=C(C1=C(O)C(C)=NC=C1CO)O

Molecular Formula

C8H9NO4

Molecular Weight

183.16

Precautions

H315, H319, H335

References & Citations

[1]Yoshimura N, et al. Urinary 4-pyridoxic acid as a non-invasive biomarker for evaluating osteoarthritis severity: findings from the ROAD study. Aging Clin Exp Res. 2025 Feb 25;37 (1) :50.|[2]Sullivan DW Jr, et al. A 7-day intravenous toxicity study and neurotoxicity assessment of pyridorin in Sprague-Dawley rats. Hum Exp Toxicol. 2017 Jul;36 (7) :718-726.|[3]Tan SPF, et al. Development of 4-Pyridoxic Acid PBPK Model to Support Biomarker-Informed Evaluation of OAT1/3 Inhibition and Effect of Chronic Kidney Disease. Clin Pharmacol Ther. 2023 Dec;114 (6) :1243-1253.|[4]Sharma SK, et al. Determination of vitamin B6 vitamers and pyridoxic acid in biological samples. J Chromatogr. 1992 Jul 1;578 (1) :45-51.