SPEN-IN-1
SPEN-IN-1 (compound X1) is an inhibitor of SPEN which is a protein factor with a Kd value of 47 nM. SPEN-IN-1 has high selectivity for RepA, a 431-nucleotide domain in Xist (a non-coding RNA prototype) that comprises 8.5 units of a GC-rich motif responsible for gene silencing[1].
Product Specifications
CAS Number
2863686-82-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/spen-in-1.html
Purity
97.09
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
C1(C2=NC3=CC=CC=C3N2)=NNC4=C1C=C(C5=CC=CC(OCC6=CC=CC=C6)=C5)C=C4
Molecular Formula
C27H20N4O
Molecular Weight
416.47
Precautions
H302, H315, H319
References & Citations
[1]Aguilar R, et al. Targeting Xist with compounds that disrupt RNA structure and X inactivation. Nature. 2022 Apr;604 (7904) :160-166.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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