SPEN-IN-1
SPEN-IN-1 (compound X1) is an inhibitor of SPEN which is a protein factor with a Kd value of 47 nM. SPEN-IN-1 has high selectivity for RepA, a 431-nucleotide domain in Xist (a non-coding RNA prototype) that comprises 8.5 units of a GC-rich motif responsible for gene silencing[1].
Product Specifications
CAS Number
[2863686-82-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/spen-in-1.html
Purity
97.09
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
C1(C2=NC3=CC=CC=C3N2)=NNC4=C1C=C(C5=CC=CC(OCC6=CC=CC=C6)=C5)C=C4
Molecular Formula
C27H20N4O
Molecular Weight
416.47
Precautions
H302, H315, H319
References & Citations
[1]Aguilar R, et al. Targeting Xist with compounds that disrupt RNA structure and X inactivation. Nature. 2022 Apr;604 (7904) :160-166.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Chicken Ectonucleoside triphosphate diphosphohydrolase 5 ELISA Kit
Chicken Ectonucleoside triphosphate diphosphohydrolase 5 ELISA Kit
Chicken Ectonucleoside triphosphate diphosphohydrolase 5 ELISA Kit