Sigma-1 receptor antagonist 2
Sigma-1 receptor antagonist 2 is a potent and selective sigma 1 receptor (σ1 R) antagonist with Kis of 3.88 and 1288 nM for σ1 and σ2 receptor, respectively[1].
Product Specifications
CAS Number
[1639220-15-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Sigma Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sigma-1-receptor-antagonist-2.html
Purity
99.76
Solubility
DMSO : 86.67 mg/mL (ultrasonic)
Smiles
CC1=NC(C2=CC=C(OC)C=C2)=NC(OCCCN3CCCCC3)=C1Cl
Molecular Formula
C20H26ClN3O2
Molecular Weight
375.89
Precautions
H302, H315, H319
References & Citations
[1]Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57 (24) :10404-23.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Sigma 1 Receptor
Available Sizes
Curated Selection
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