β-Amyloid (31-35)

β-Amyloid (31-35) is the shortest sequence of native Amyloid-β peptide that retains neurotoxic activity.

Product Specifications

CAS Number

[149385-65-9]

UNSPSC

12352209

Target

Amyloid-β

Type

Peptides

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/_beta_-Amyloid_31-35.html

Purity

99.10

Solubility

DMSO : 5 mg/mL (ultrasonic; adjust pH to 7 with HCl)

Smiles

O=C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(O)=O)=O)=O)=O)[C@H]([C@@H](C)CC)N

Molecular Formula

C25H47N5O6S

Molecular Weight

545.74

References & Citations

[1]Milton NG, et al. The amyloid-beta peptide binds to cyclin B1 and increases human cyclin-dependent kinase-1 activity. Neurosci Lett. 2002 Apr 5;322 (2) :131-3.|[2]Misiti F, et al. Fragment 31-35 of beta-amyloid peptide induces neurodegeneration in rat cerebellar granule cells via bax gene expression and caspase-3 activation. A crucial role for the redox state of methionine-35 residue. Neurochem Int. 2006 Oct;49 (5) :525-32.|[3]M Jesús Pérez de Vega, et al. Synthesis and biological properties of beta-turned Abeta (31-35) constrained analogues. Bioorg Med Chem Lett. 2008 Mar 15;18 (6) :2078-82.