Piromelatine
Piromelatine (Neu-P11) is a melatonin MT1/MT2 receptor agonist, serotonin 5-HT1A/5-HT1D agonist, and serotonin 5-HT2B antagonist. Piromelatine (Neu-P11) possesses sleep promoting, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potentials. Piromelatine (Neu-P11) also possesses pain-related P2X3, TRPV1, and Nav1.7 channel-inhibition capacities[1][2][3].
Product Specifications
CAS Number
946846-83-9
Product Name Alternative
Neu-P11
UNSPSC
12352005
Target
5-HT Receptor; Melatonin Receptor; P2X Receptor; Sodium Channel; TRP Channel
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/piromelatine.html
Purity
99.54
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(C=CO1)=O)NCCC2=CNC3=CC=C(OC)C=C23
Molecular Formula
C17H16N2O4
Molecular Weight
312.32
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
5-HT1 Receptor;5-HT2 Receptor; mLAG-3; MT1; MT2; P2X3 Receptor; α-1 microglobulin
Available Sizes
Frequently Asked Questions
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