Piromelatine

Piromelatine (Neu-P11) is a melatonin MT1/MT2 receptor agonist, serotonin 5-HT1A/5-HT1D agonist, and serotonin 5-HT2B antagonist. Piromelatine (Neu-P11) possesses sleep promoting, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potentials. Piromelatine (Neu-P11) also possesses pain-related P2X3, TRPV1, and Nav1.7 channel-inhibition capacities[1][2][3].

Product Specifications

CAS Number

[946846-83-9]

Product Name Alternative

Neu-P11

UNSPSC

12352005

Target

5-HT Receptor; Melatonin Receptor; P2X Receptor; Sodium Channel; TRP Channel

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/piromelatine.html

Purity

99.54

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(C=CO1)=O)NCCC2=CNC3=CC=C(OC)C=C23

Molecular Formula

C17H16N2O4

Molecular Weight

312.32

References & Citations

[1]Meihua She, et al. Piromelatine, a Novel Melatonin Receptor Agonist, Stabilizes Metabolic Profiles and Ameliorates Insulin Resistance in Chronic Sleep Restricted Rats. Eur J Pharmacol. 2014 Mar 15;727:60-5.|[2]L Huang, et al. Blood Pressure Reducing Effects of Piromelatine and Melatonin in Spontaneously Hypertensive Rats. Eur Rev Med Pharmacol Sci. 2013 Sep;17 (18) :2449-56.|[3]Yuan-Yuan Liu, et al. Piromelatine Exerts Antinociceptive Effect via Melatonin, Opioid, and 5HT1A Receptors and Hypnotic Effect via Melatonin Receptors in a Mouse Model of Neuropathic Pain. Psychopharmacology (Berl) . 2014 Oct;231 (20) :3973-85.