Wogonin
Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of CDK8 and Wnt, and exhibits anti-inflammatory and anti-tumor effects.
Product Specifications
CAS Number
632-85-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; CDK; Wnt
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Wogonin.html
Purity
99.92
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C1C=C(C2=CC=CC=C2)OC3=C(OC)C(O)=CC(O)=C13
Molecular Formula
C16H12O5
Molecular Weight
284.26
Precautions
H302, H315, H319, H335
References & Citations
[1]He L, et al. Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells. Toxicology. 2013 Oct 4;312:36-47.|[2]Yang L, et al. Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21Cip1 in human cervical carcinoma HeLa cells. Biochem Cell Biol. 2009 Dec;87 (6) :933-42.|[3]Li HD, et al. Wogonin attenuates inflammation by activating PPAR-γ in alcoholic liver disease. Int Immunopharmacol. 2017 Sep;50:95-106.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CDK8
Available Sizes
Frequently Asked Questions
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