Seribantumab
Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models[1].
Product Specifications
CAS Number
1334296-12-6
Product Name Alternative
SAR 256212; MM 121; Anti-Human ERBB3/ErbB 3 Recombinant Antibody
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; EGFR
Type
Inhibitory Antibodies
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/seribantumab.html
Purity
96.043
Solubility
10 mM in DMSO
Smiles
[Seribantumab]
Molecular Weight
(143.14 kDa)
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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