Ranitidine

Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist that inhibits gastric secretion. Ranitidine antagonizes Histamine (HY-B1204) -induced increases of the guinea-pig isolated rat atrium and Histamine-induced relaxations of the rat isolated uterine horn, with pA2 values of 7.2 and 6.95, respectively. Ranitidine inhibits breast tumor development and spread in mice[1][2].

Product Specifications

CAS Number

[66357-35-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ranitidine.html

Concentration

10mM

Purity

99.9

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=[N+](/C=C(NC)/NCCSCC1=CC=C(CN(C)C)O1)[O-]

Molecular Formula

C13H22N4O3S

Molecular Weight

314.40

Precautions

H315, H319, H320

References & Citations

[1]Daly MJ, et al. Some in vitro and in vivo actions of the new histamine H2-receptor antagonist, ranitidine. Br J Pharmacol. 1981 Jan;72 (1) :49-54.|[2]Vila-Leahey A, et al. Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice. Oncoimmunology. 2016 Mar 10;5 (7) :e1151591.