IL-22, Mouse (His-Avi)

IL-22 Protein is an secreted IL-10 family cytokine that take part in inflammation responses, reactive oxygen species metabolic process as well as the regeneration and spreading of epithelial cells. IL22 promotes cell survival and proliferation through STAT3, ERK1/2, MAPK and PI3K/AKT pathways. IL-22 Protein, Mouse (His-Avi) is the recombinant mouse-derived IL-22 protein, expressed by E. coli , with N-His, N-Avi labeled tag.

Product Specifications

Product Name Alternative

IL-22 Protein, Mouse (His-Avi), Mouse, E. coli

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/il-22-protein-mouse-his-avi.html

Molecular Formula

50929 (Gene_ID) Q9JJY9 (L34-V179) (Accession)

Molecular Weight

Approximately 20 kDa, based on SDS-PAGE under reducing conditions.

References & Citations

[1]Saxton RA, et al. The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design. Immunity. 2021 Apr 13;54 (4) :660-672.e9.|[2]Delbue D, et al. Reprogramming Intestinal Epithelial Cell Polarity by Interleukin-22. Front Med (Lausanne) . 2021 Apr 12;8:656047.|[3]Weathington NM, et al. Glycogen synthase kinase-3β stabilizes the interleukin (IL) -22 receptor from proteasomal degradation in murine lung epithelia. J Biol Chem. 2014 Jun 20;289 (25) :17610-9.|[4]Wei CC, et al. Cloning and characterization of mouse IL-22 binding protein. Genes Immun. 2003 Apr;4 (3) :204-11.|[5]Dudakov JA, et al. Interleukin-22: immunobiology and pathology. Annu Rev Immunol. 2015;33:747-85.

Shipping Conditions

Dry ice.

Scientific Category