Daclatasvir (dihydrochloride) (Standard)

Daclatasvir (dihydrochloride) (Standard) is the analytical standard of Daclatasvir (dihydrochloride) . This product is intended for research and analytical applications. Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) is a potent and orally active HCV NS5A protein inhibitor with EC50s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir dihydrochloride is also an organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC50s of 1.5 µM and 3.27 µM, respectively[1][2][3].

Product Specifications

CAS Number

[1009119-65-6]

Product Name Alternative

BMS-790052 (dihydrochloride) (Standard) ; EBP 883 (dihydrochloride) (Standard)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HCV; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Others

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/daclatasvir-dihydrochloride-standard.html

Purity

99.65

Smiles

O=C(N1CCC[C@H]1C2=NC=C(C3=CC=C(C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C([C@H](C(C)C)NC(OC)=O)=O)C=C3)N2)[C@H](C(C)C)NC(OC)=O.[H]Cl.[H]Cl

Molecular Formula

C40H52Cl2N8O6

Molecular Weight

811.80

Precautions

H302, H315, H319, H335

References & Citations

[1]Min Gao, et al. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature. 2010 May 6;465 (7294) :96-100.|[2]David B Ascher, et al. Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA. Sci Rep. 2014 Apr 23;4:4765.|[3]Tomomi Furihata, et al. Different interaction profiles of direct-acting anti-hepatitis C virus agents with human organic anion transporting polypeptides. Antimicrob Agents Chemother. 2014 Aug;58 (8) :4555-64.|[4]Seung-Hoon Lee, et al. HA1077 displays synergistic activity with daclatasvir against hepatitis C virus and suppresses the emergence of NS5A resistance-associated substitutions in mice. Sci Rep. 2018 Aug 20;8 (1) :12469.