Rolapitant (hydrochloride hydrate)
Rolapitant hydrochloride hydrate (SCH619734 hydrochloride hydrate) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant hydrochloride hydrate does not interact with CYP3A4. Rolapitant hydrochloride hydrate shows potent anti-emetic activity in a ferret emesis model[1][2].
Product Specifications
CAS Number
914462-92-3
Product Name Alternative
SCH619734 (hydrochloride hydrate)
UNSPSC
12352005
Hazard Statement
H302
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rolapitant-hydrochloride-hydrate.html
Purity
98.25
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C1N[C@]2(CN[C@@](C3=CC=CC=C3)(CO[C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C)CC2)CC1.[H]Cl.O
Molecular Formula
C25H29ClF6N2O3
Molecular Weight
554.95
Precautions
H302
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
NK1R
Available Sizes
Frequently Asked Questions
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