Sar-Arg-Val-Tyr-Val-His-NH2

Sar-Arg-Val-Tyr-Val-His-NH2 is a Gq-biased agonists, exhibits 10-fold larger molecular efficacies at the AT1R-Gq fusion protein compared with the AT1R-βarr2 fusion protein[1].

Product Specifications

CAS Number

[2410957-04-7]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Angiotensin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/trv120055.html

Purity

96.63

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](C(C)C)C(N[C@@H](CC2=CNC=N2)C(N)=O)=O)=O)=O)=O)CNC

Molecular Formula

C34H54N12O7

Molecular Weight

742.87

Precautions

H302, H315, H319, H335

References & Citations

[1]Strachan RT, et, al. Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR) . J Biol Chem. 2014 May 16; 289 (20) : 14211-24.|[2]Rajagopal S, et, al. Quantifying ligand bias at seven-transmembrane receptors. Mol Pharmacol. 2011 Sep;80 (3) :367-77.