Sar-Arg-Val-Tyr-Val-His-NH2
Sar-Arg-Val-Tyr-Val-His-NH2 is a Gq-biased agonists, exhibits 10-fold larger molecular efficacies at the AT1R-Gq fusion protein compared with the AT1R-βarr2 fusion protein[1].
Product Specifications
CAS Number
2410957-04-7
UNSPSC
12352209
Hazard Statement
H302, H315, H319, H335
Target
Angiotensin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/trv120055.html
Purity
96.63
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](C(C)C)C(N[C@@H](CC2=CNC=N2)C(N)=O)=O)=O)=O)=O)CNC
Molecular Formula
C34H54N12O7
Molecular Weight
742.87
Precautions
H302, H315, H319, H335
References & Citations
[1]Strachan RT, et, al. Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR) . J Biol Chem. 2014 May 16; 289 (20) : 14211-24.|[2]Rajagopal S, et, al. Quantifying ligand bias at seven-transmembrane receptors. Mol Pharmacol. 2011 Sep;80 (3) :367-77.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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