Nicastrin, Mouse (HEK293, His)

Nicastrin is an important subunit of the γ-secretase complex and plays a key role in the endoproteolytic cleavage of integral membrane proteins, including Notch receptors and amyloid-β precursor protein (APP). In the γ-secretase complex, nicastin acts as a key regulator of Notch and Wnt signaling cascades and affects downstream processes. Nicastrin Protein, Mouse (HEK293, His) is the recombinant mouse-derived Nicastrin protein, expressed by HEK293 , with C-His labeled tag. The total length of Nicastrin Protein, Mouse (HEK293, His) is 641 a.a., with molecular weight of 95-99 kDa.

GLCGGNSVER KIYIPLNKTA PCVRLLNATH QIGCQSSISG DTGVIHVVEK EEDLKWVLTD GPNPPYMVLL EGKLFTRDVM EKLKGTTSRI AGLAVTLAKP NSTSSFSPSV QCPNDGFGIY SNSYGPEFAH CKKTLWNELG NGLAYEDFSF PIFLLEDENE TKVIKQCYQD HNLGQNGSAP SFPLCAMQLF SHMHAVISTA TCMRRSFIQS TFSINPEIVC DPLSDYNVWS MLKPINTSVG LEPDVRVVVA ATRLDSRSFF WNVAPGAESA VASFVTQLAA AEALHKAPDV TTLSRNVMFV FFQGETFDYI GSSRMVYDME NGKFPVRLEN IDSFVELGQV ALRTSLDLWM HTDPMSQKNE SVKNQVEDLL ATLEKSGAGV PEVVLRRLAQ SQALPPSSLQ RFLRARNISG VVLADHSGSF HNRYYQSIYD TAENINVTYP EWQSPEEDLN FVTDTAKALA NVATVLARAL YELAGGTNFS SSIQADPQTV TRLLYGFLVR ANNSWFQSIL KHDLRSYLDD RPLQHYIAVS SPTNTTYVVQ YALANLTGKA TNLTREQCQD PSKVPNESKD LYEYSWVQGP WNSNRTERLP QCVRSTVRLA RALSPAFELS QWSSTEYSTW AESRWKDIQA RIFLIASKEL E