2-AEMP
2-AEMP (2-Aminoethyl methylphosphonate) is an anti-GABA (A) -ρ1 receptor compound with antagonist activity. 2-AEMP exhibits competitive inhibition compared to TPMPA with an IC (50) value of 18 μM, compared to 7 μM for TPMPA. The release rate of inhibition at termination of 2-AEMP is significantly higher than that of TPMPA. The preincubation time required for the onset of inhibition of 2-AEMP is much shorter than that of TPMPA. Some analogs of 2-AEMP, especially those with benzyl or n-butyl substituents, show lower potency in terms of biological activity[1].
Product Specifications
CAS Number
321882-95-5
Product Name Alternative
2-Aminoethyl methylphosphonate
UNSPSC
12352211
Hazard Statement
H301
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2-aemp.html
Smiles
CP(OCCN)(O)=O
Molecular Formula
C3H10NO3P
Molecular Weight
139.09
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]2-Aminoethyl methylphosphonate, a potent and rapidly acting antagonist of GABA (A) -ρ1 receptors
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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