GSK-114
GSK-114 is a highly selective, orally active TNNI3K inhibitor (IC50= 25 nM) . GSK-114 shows a 40-fold selectivity for TNNI3K over B-Raf kinase (IC50= 1 μM) . Cardiac troponin I-interacting kinase (TNNI3K or CARK) is a member of the tyrosine-like kinase family that is selectively expressed in heart tissue[1].
Product Specifications
CAS Number
1301761-96-5
Product Name Alternative
(Z)-Mutagenic Impurity of Tenofovir Disoproxil,BMS-387032,Mutagenic Impurity of Tenofovir Disoproxil (Standard); Tenofovir Impurity 2 (Standard)
UNSPSC
12352005
Hazard Statement
H315, H319
Target
MAP3K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/gsk-114.html
Purity
99.52
Solubility
DMSO : 5.95 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S(NC)(C1=CC=C(N(C)C)C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)=C1)=O
Molecular Formula
C19H23N5O4S
Molecular Weight
417.48
Precautions
H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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