Concanamycin A

Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H+-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research[1]-[5].

Product Specifications

CAS Number

[80890-47-7]

Product Name Alternative

Antibiotic X 4357B; Folimycin; X 4357B

UNSPSC

12352005

Hazard Statement

H300, H310, H319, H330

Target

Antibiotic; Bacterial; Proton Pump

Type

Natural Products

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/concanamycin-a.html

Purity

99.84

Solubility

DMSO : ≥ 10 mg/mL

Smiles

C[C@H]([C@@](C[C@H]1O[C@@](O[C@H](C)[C@H]2OC(N)=O)([H])C[C@H]2O)(O[C@H](/C=C/C)[C@H]1C)O)[C@H](O)[C@@H]([C@](OC(/C(OC)=C/C(C)=C/[C@H]([C@@H](O)[C@H]3CC)C)=O)([H])[C@H](/C=C/C=C(C[C@H]([C@@H]3O)C)/C)OC)C

Molecular Formula

C46H75NO14

Molecular Weight

866.09

Precautions

H300, H310, H319, H330

References & Citations

[1]Togashi K, et al. Concanamycin A, a vacuolar type H (+) -ATPase inhibitor, induces cell death in activated CD8 (+) CTL. Cytotechnology. 1997 Nov;25 (1-3) :127-35.|[2]Eswarappa SM, et al. Folimycin (concanamycin A) inhibits LPS-induced nitric oxide production and reduces surface localization of TLR4 in murine macrophages. Innate Immun. 2008 Feb;14 (1) :13-24.|[3]Hines IN, et al. Impaired T cell-mediated hepatitis in peroxisome proliferator activated receptor alpha (PPARα) -deficient mice. Biol Res. 2018 Feb 15;51 (1) :5.|[4]Woo JT, et al. Isolation, characterization and biological activities of concanamycins as inhibitors of lysosomal acidification. J Antibiot (Tokyo) . 1992 Jul;45 (7) :1108-16.|[5]Vaněk, Z., et al. Immunomodulators isolated from microorganisms. Folia Microbiol. 1991. 36:99–111.