VU6010572

VU6010572 is a potent and selective mGlu3 negative allosteric modulator with IC50 of 245 nM. VU6010572 is highly CNS penetrant[1][2].

Product Specifications

CAS Number

[2126784-39-0]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vu6010572.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=C(OC[C@@H](OC2=CC=CC=C2)C)C=CN1C3=CC=C(F)C=C3

Molecular Formula

C20H18FNO3

Molecular Weight

339.36

References & Citations

[1]Engers JL, et al. Design and Synthesis of N-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs. ACS Med Chem Lett. 2017;8 (9) :925-930. Published 2017 Aug 15.|[2]Ryan E. Tyler1, et al. The effects of predator odor (TMT) exposure and mGlu3 NAM pretreatment on lasting behavioral and molecular adaptations in the insular cortex and BNST