Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

EPAC 5376753

EPAC 5376753, a 2-Thiobarbituric acid derivative, is a selective and allosteric Epac inhibitor. EPAC 5376753 inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells. EPAC 5376753 does not inhibit PKA and adenylyl cyclases[1].

Product Specifications

CAS Number

302826-61-5

UNSPSC

12352005

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/EPAC_5376753.html

Purity

98.10

Solubility

10 mM in DMSO

Smiles

O=C(/C(C(N1)=O)=C/C2=CC=C(C3=CC=C(Cl)C=C3Cl)O2)NC1=S

Molecular Formula

C15H8Cl2N2O3S

Molecular Weight

367.21

References & Citations

[1]Brown LM, et al. Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors. J Biol Chem. 2014 Oct 17;289 (42) :29148-57.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

HSPB2 (NM_001541) Human Over-expression Lysate
LC419871 20 µg

HSPB2 (NM_001541) Human Over-expression Lysate

Sign In for Pricing
View Details
Human Gcn1l1 (GCN1) activation kit by CRISPRa
GA107542 1 Kit

Human Gcn1l1 (GCN1) activation kit by CRISPRa

Sign In for Pricing
View Details
Prm2 Mouse Gene Knockout Kit (CRISPR)
KN513931 1 Kit

Prm2 Mouse Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
MIR6853 Human qPCR Primer Pair (MI0022699)
HP301453 200 Reactions

MIR6853 Human qPCR Primer Pair (MI0022699)

Sign In for Pricing
View Details
MART-1 / Melan-A / MLANA (Melanoma Marker) (rMLANA/788), CF647 conjugate, 0.1mg/mL
BNC471812-100 1x 100 µL

MART-1 / Melan-A / MLANA (Melanoma Marker) (rMLANA/788), CF647 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
p53 DINP1 Recombinant Rabbit Monoclonal Antibody [JG37-64]
ET7108-35 100 µL

p53 DINP1 Recombinant Rabbit Monoclonal Antibody [JG37-64]

Sign In for Pricing
View Details