Vebicorvir
Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor. Vebicorvir (ABI-H0731) suppresses covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC50s from 1.84 μM to 7.3 μM[1].
Product Specifications
CAS Number
[2090064-66-5]
Product Name Alternative
ABI-H0731
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HBV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/vebicorvir.html
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C(NC(C2=CC=CC=C23)=O)=C1)S3(=O)=O)NCC4=CN=C(C(F)(F)F)S4
Molecular Formula
C19H12F3N3O4S2
Molecular Weight
467.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Qi Huang, et al. Preclinical Profile and Characterization of the Hepatitis B Virus Core Protein Inhibitor ABI-H0731. Antimicrob Agents Chemother. 2020 Oct 20;64 (11) :e01463-20.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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