Rasagiline (mesylate)

Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively[1]. Rasagiline (mesylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[161735-79-1]

Product Name Alternative

(R) -AGN1135 (mesylate) ; TVP1012 (mesylate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Monoamine Oxidase

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rasagiline-mesylate.html

Purity

99.82

Solubility

H2O : 25 mg/mL (ultrasonic)

Smiles

CS(=O)(O)=O.C#CCN[C@H]1C2=CC=CC=C2CC1

Molecular Formula

C13H17NO3S

Molecular Weight

267.34

Precautions

H302, H315, H319, H335

References & Citations

[1]M B Youdim, et al. Rasagiline [N-propargyl-1R (+) -aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B. Br J Pharmacol. 2001 Jan;132 (2) :500-6.|[2]Nadia Stefanova, et al. Rasagiline is neuroprotective in a transgenic model of multiple system atrophy. Exp Neurol. 2008 Apr;210 (2) :421-7.|[3]Shawna Tazik, et al. Comparative neuroprotective effects of Rasagiline and aminoindan with selegiline on dexamethasone-induced brain cell apoptosis. Neurotox Res. 2009 Apr;15 (3) :284-90.