Deacylketoconazole

Deacylketoconazole (N-Deacetylketoconazole; R-39519) is an orally active metabolite of Ketoconazole (HY-B0105) . Deacylketoconazole exhibits antifungal and antibacterial activity. Deacylketoconazole is cytotoxic in rats hepatocyte[1][2][3].

Product Specifications

CAS Number

[67914-61-8]

Product Name Alternative

N-Deacetylketoconazole; R-39519

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/deacylketoconazole.html

Purity

99.60

Solubility

DMSO : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

ClC1=CC=C(C(Cl)=C1)[C@@]2(OC[C@H](O2)COC3=CC=C(C=C3)N4CCNCC4)CN5C=CN=C5

Molecular Formula

C24H26Cl2N4O3

Molecular Weight

489.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Pfaller MA, et al., Activity of ketoconazole and its deacyl derivative against Plasmodium falciparum and Candida isolates. Antimicrob Agents Chemother. 1982 Nov;22 (5) :917-9.|[2]Bossche H V, et al., Molecular basis for the antimycotic and antibacterial activity of N‐substituted imidazoles and triazoles: The inhibition of isoprenoid biosynthesis[J]. Pesticide science, 1984, 15 (2) : 188-198.|[3]Fukami T, et al., Human arylacetamide deacetylase hydrolyzes ketoconazole to trigger hepatocellular toxicity. Biochem Pharmacol. 2016 Sep 15;116:153-61.