MC-Val-Cit-PAB-NH-C2-NH-Boc
MC-Val-Cit-PAB-NH-C2-NH-Boc is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
[1616727-22-0]
UNSPSC
12352203
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc-val-cit-pab-nh-c2-nh-boc.html
Purity
95.0
Solubility
10 mM in DMSO
Smiles
CC(C)(C)OC(NCCNC(OCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN2C(C=CC2=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C36H54N8O10
Molecular Weight
758.86
References & Citations
[1]Akaiwa M, et al. Synthesis and Evaluation of Linear and Macrocyclic Dolastatin 10 Analogues Containing Pyrrolidine Ring Modifications. ACS Omega. 2018;3 (5) :5212-5221.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Protease Cleavable Linker
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
LV708709 1.0 µg DNA
CHMP5 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)
Sign In for Pricing
View Details 
GTR15200725 1 Vial
Lentiviral mouse Lyrm7 shRNA (UAS) - Lentiviral mouse Lyrm7 shRNA (UAS, RFP) plasmid
Sign In for Pricing
View Details RPU51990-01 50 µg
Recombinant Human Chemokine (C-X-C Motif) Ligand 1 (CXCL1)
Sign In for Pricing
View Details