(Rac) -PF-06256142
(Rac) -PF-06256142 is the less effective enantiomer of PF-06256142 (HY-119943) . (Rac) -PF-06256142 is an agonist of D1 receptor, with an EC50 of 107 nM. (Rac) -PF-06256142 can be used for the research of schizophrenia and Parkinson's disease[1].
Product Specifications
CAS Number
[1609580-97-3]
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rac-pf-06256142.html
Purity
99.59
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC1=C(C2=C(C)N=CC3=NC=CN32)C=CC(OC4=C(C=CO5)C5=CC=N4)=C1
Molecular Formula
C21H16N4O2
Molecular Weight
356.38
References & Citations
[1]Davoren JE, et al. Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization. J Med Chem. 2018 Nov 15.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D1 Receptor
Available Sizes
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