UPF 1069

UPF 1069 is a PARP inhibitor, with IC50s of 8 and 0.3 μM for PARP-1 and PARP-2, respectively.

Product Specifications

CAS Number

[1048371-03-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/UPF-1069.html

Concentration

10mM

Purity

99.02

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1NC=CC2=C1C=CC=C2OCC(C3=CC=CC=C3)=O

Molecular Formula

C17H13NO3

Molecular Weight

279.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Pellicciari R, et al. On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives. ChemMedChem. 2008 Jun;3 (6) :914-23.|[2]Moroni F, et al. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage.