UPF 1069
Product Specifications
UNSPSC Description
UPF 1069 is a PARP inhibitor, with IC50s of 8 and 0.3 μM for PARP-1 and PARP-2, respectively.
Target Antigen
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/UPF-1069.html
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1NC=CC2=C1C=CC=C2OCC(C3=CC=CC=C3)=O
Molecular Weight
279.29
References & Citations
[1]Pellicciari R, et al. On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives. ChemMedChem. 2008 Jun;3(6):914-23.|[2]Moroni F, et al. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14478/UPF-1069-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14478/UPF-1069-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1048371-03-4
Available Sizes
Curated Selection
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